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DiscoverX PathHunter™ eXpress NMBR Total GPCR Internalization Assay

Product Code. 17354049
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Quantity:
200 dp (2 x 96-well)
Unit Size:
1 set
Product Code. Quantity unitSize
17354049 200 dp (2 x 96-well) 1 set
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Product Code. 17354049

Brand: DiscoverX 930939E3CP5M

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This item is not returnable. View return policy

Description

The PathHunter™ eXpress NMBR Total GPCR Internalization Assay measures NMBR (GPCR) internalization via early-endosome localization. eXpress kits contain all assay materials: cells, reagents, and plates.

The PathHunter™ NMBR Total GPCR internalization eXpress kit provides an easy to-use cell based assay to study drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This kit assesses ligand (e.g. neuromedin B) based internalization of NMBR via detection of localization to the early endosome. This product uses EFC technology. The included cells overexpress PK-tagged NMBR and an EA-tagged early endosome protein. Upon ligand-induced receptor activation, resulting internalization of the NMBR receptor to the early endosome leads to production of EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates.

Specifications

Assay Entry Total Internalization
For Use With (Application) Assay-Ready eXpress Kits
Primary Agonist Neuromedin B (porcine)
Quantity 200 dp (2 x 96-well)
Target Entry NMBR
Cell Line U2OS
Target NMBR
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