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  6. PARL Rabbit anti-Human, Polyclonal, Proteintech

PARL Rabbit anti-Human, Polyclonal, Proteintech

Product Code. p-7211886 Shop All Proteintech Products
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Quantity:
150 μL
20 μL
Unit Size:
150µL
20µL
Product Code. Quantity unitSize
16865075 20 μL 20µL
16855075 150 μL 150µL
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Product Code. 16865075

Brand: Proteintech 266791AP20UL

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Description

Rabbit Polyclonal Antibody

PARL is a mitochondrial integral membrane protein and a member of the highly conserved rhomboid superfamily of membrane proteins. PARL is required for the control of apoptosis during postnatal growth and is required for the processing of OPA1, a protein that prevents the release of cytochrome C from the mitochondria in response to apoptotic signals. In lymphocytes and neurons, PARL′s association with other proteins, such as the Bcl-2 family-related protein Hax1 and Omi can lead to the proteolytic processing of Omi by PARL, preventing the accumulation of Bax, thereby suppressing apoptosis. Variations in this gene have been associated with increased risk for type 2 diabetes. PARL may also play a role in the progression of Alzheimer′s disease through its associations with presenilin-1 and -2. Multiple isoforms of PARL are known to exist.

Specifications

Antigen PARL
Applications Western Blot, Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.47 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Gene PARL
Gene Accession No. Q9H300
Gene Alias PARL, Pbeta, PRO2207, PSARL, PSARL1, PSENIP2, RHBDS1
Gene Symbols PARL
Host Species Rabbit
Immunogen PARL Fusion Protein Ag24789
Purification Method Antigen Affinity Chromatography
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 55486
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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