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  6. PAG1 Rabbit anti-Human, Mouse, Polyclonal, Proteintech

PAG1 Rabbit anti-Human, Mouse, Polyclonal, Proteintech

Product Code. 16803565 Shop All Proteintech Products
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Quantity:
150 μL
20 μL
Unit Size:
150µL
20µL
Product Code. Quantity unitSize
16803565 20 μL 20µL
16893555 150 μL 150µL
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Product Code. 16803565

Brand: Proteintech 250291AP20UL

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Description

Rabbit Polyclonal Antibody

PAG (phosphoprotein associated with GEMs), also known as Cbp (Csk-binding protein), is a ubiquitously expressed 46 kDa transmembrane adaptor protein present in membrane rafts (glycosphingolipid-enriched microdomains), which however migrates on SDS PAGE gels anomalously as an 80 kDa molecule. Following tyrosine phosphorylation by Src family kinases, PAG binds and thereby activates the protein tyrosine kinase Csk, the major negative regulator of the Src family kinases. Signaling via the B-cell receptor in B cells or high affinity IgE receptor (FcepsilonRI) in mast cells leads to PAG increased tyrosine phosphorylation and Csk binding, while T cell receptor signaling causes PAG dephosphorylation, loss of Csk binding and increased activation of the protein tyrosine kinase Lck.

Specifications

Antigen PAG1
Applications Western Blot
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Gene PAG1
Gene Accession No. Q3U1F9, Q9NWQ8
Gene Alias CBP, Csk binding protein, PAG, PAG1
Gene Symbols PAG1
Host Species Rabbit
Immunogen PAG1 Fusion Protein Ag13393
Purification Method Antigen Affinity Chromatography
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 55824, 94212
Target Species Mouse, Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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