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Description
This gene encodes a member of the family of neuronal petraxins, synaptic proteins that are related to C-reactive protein. This protein is involved in excitatory synapse formation. It also plays a role in clustering of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors at established synapses, resulting in non-apoptotic cell death of dopaminergic nerve cells. Up-regulation of this gene in Parkinson disease (PD) tissues suggests that the protein may be involved in the pathology of PD.
Specifications
Specifications
| Antigen | NPTX2 |
| Applications | Immunohistochemistry (Paraffin), Western Blot, Immunoprecipitation |
| Classification | Polyclonal |
| Concentration | 0.26 mg/mL |
| Conjugate | Unconjugated |
| Formulation | PBS with 50% glycerol and 0.1% sodium azide; pH 7.3 |
| Gene | NPTX2 |
| Gene Accession No. | O70340, P47972, P97738 |
| Gene Alias | NARP, Neuronal pentraxin 2, neuronal pentraxin II, NPTX2 |
| Gene Symbols | Nptx2 |
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