missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Cell Culture Media, Supplements, and Reagents
  4. Cell Culture Reagents, Antibiotics and Supplements
  5. Antibiotics
  6. Novobiocin Sodium Salt, MP Biomedicals™

Novobiocin Sodium Salt, MP Biomedicals™

Product Code. 17660877 Shop All MP Biomedicals Products
Change view
Click to view available options
Quantity:
1 g
5 g
25 g
100 g
Unit Size:
100g
1g
25g
5g
Product Code. Quantity unitSize
17660877 1 g 1g
11489251 5 g 5g
11499251 25 g 25g
11409261 100 g 100g
4 options
This item is not returnable. View return policy

Product Code. 17660877

Brand: MP Biomedicals 0215595701

Please to purchase this item. Need a web account? Register with us today!

This item is not returnable. View return policy

Description

Inhibits DNA synthesis by inhibiting the enzyme Topoisomerase II. Novobiocin Sodium Salt, MP Biomedicals is an antibiotic produced by Streptomyces nieveus. It is active against gram-positive bacteria. It is also a Hsp90 inhibitor 3.

Novobiocin inhibits DNA synthesis by inhibiting bacterial DNA gyrase targeting the GyrB subunit of the enzyme involved in energy transduction. It acts as a competitive inhibitor of the ATPase reaction catalysed by GyrB 2. Uses include:

  • For the production of positively supercoiled plasmid DNA
  • Inhibitor of bacterial DNA gyrase and eukaryotic DNA topoisomerase
  • Inhibitor of retrovirus RNA-dependent DNA-polymerase
  • To study heat shock protein inhibition
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 1476-53-5
Molecular Formula C31H35N2NaO11
Molecular Weight (g/mol) 634.61
MDL Number MFCD00066541,MFCD00066541
InChI Key AXOUUAINTJNFRS-UHFFFAOYNA-N
Synonym Albamycin, Cathomycin sodium
PubChem CID 131673945
SMILES [Na+].COC1C(OC(N)=O)C(O)C(OC2=CC=C3C(=O)[C-](NC(=O)C4=CC=C(O)C(CC=C(C)C)=C4)C(=O)OC3=C2C)OC1(C)C

Specifications

Physical Form Powder
Absorbance λ max: 307nm
Melting Point 220°C
Extinction Coefficient E1%= 600 (0.1M NAOH)
Potency ∼900μg/mg
Quantity 1 g
Optical Rotation −38.0° (2.5g/100ml ethanol at 24°C for the free acid)
Solubility Information Freely soluble in water (10%, clear, colorless solution)
IUPAC Name sodium 7-{[4-(carbamoyloxy)-3-hydroxy-5-methoxy-6,6-dimethyloxan-2-yl]oxy}-3-[4-hydroxy-3-(3-methylbut-2-en-1-yl)benzamido]-8-methyl-2,4-dioxo-3,4-dihydro-2H-1-benzopyran-3-ide
Formula Weight 634.6

Safety and Handling

compliance-icons
Product Identifier
  • Novobiocin Sodium Salt
 Signal Word
  • Warning
 Hazard Category
  • Serious eye damage/eye irritation Category 2
  • Skin sensitiser Category 1
 Hazard Statement
  • H317-May cause an allergic skin reaction.
  • H319-Causes serious eye irritation.
 Precautionary Statement
  • P101-If medical advice is needed, have product container or label at hand.
  • P102-Keep out of reach of children.
  • P103-Read label before use.
  • P261-Avoid breathing dust/fume/gas/mist/vapours/spray.
  • P280-Wear protective gloves/protective clothing/eye protection/face protection.
  • P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P333+P313-If skin irritation or rash occurs: Get medical advice/attention.
  • P337+P313-If eye irritation persists: Get medical advice/attention.
  • P501b-Dispose of contents/container in accordance with local/regional/national/international regulations.
 Supplemental information
  • MIXTURE LIST-Contains : Novobiocin Sodium Salt
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.