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  6. NK1.1 (CD161) Mouse, anti-Mouse, Pacific Blue, Clone: PK136, STEMCELL Technologies

NK1.1 (CD161) Mouse, anti-Mouse, Pacific Blue, Clone: PK136, STEMCELL Technologies

Product Code. 17109021
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Quantity:
100 μg
25 μg
Unit Size:
100µg
25µg
Product Code. Quantity unitSize
17109021 100 μg 100µg
17119021 25 μg 25µg
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Product Code. 17109021

Brand: Stemcell Technologies 60103PB

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Description

Mouse Monoclonal Antibody

  • The PK136 antibody reacts with murine NK1.1 (CD161), an ∼80 kDa homodimeric type 2 transmembrane glycoprotein and C-type lectin receptor expressed on NK cells, NK-T cells, and rare subsets of T cells and monocytes in select strains of mice
  • NK1.1 is encoded by the Klrb1b and Klrb1c genes, which specify CD161b and CD161c polypeptides, respectively
  • CD161b is expressed only by Swiss NIH and SJL mice, and CD161c by certain strains such as C57BL, FVB/N, and NZB (but not A, AKR, BALB/c, CBA/J, C3H, C57BR, C58, DBA/1, DBA/2, NOD, SJL, or 129)
  • NK1.1 has functional roles in modulating several processes, including the activation and proliferation of NK cells, induction of interferon-γ production, and release of cytotoxic granules
  • Its expression on the cell surface is specifically upregulated by IL-12
  • For detection of NK cells in NK1.1- strains, Anti-Mouse CD49b Antibody, Clone DX5 (Catalog #60020) is recommended
  • DX5 recognizes CD49b (integrin α2), another commonly used NK cell marker

Specifications

Antigen NK1.1 (CD161)
Applications CyTOF, Flow Cytometry, Immunocytochemistry, Immunofluorescence, Functional Assay
Classification Monoclonal
Clone PK136
Conjugate Pacific Blue
Host Species Mouse
Quantity 100 μg
Primary or Secondary Primary
Target Species Mouse
Isotype IgG2a κ
Cell Type NK Cells
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