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Niclosamide, MP Biomedicals™

Product Code. 11425031 Shop All MP Biomedicals Products
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Product Code. 11425031 Supplier MP Biomedicals Supplier No. 0215582783
  • ONLINE EXCLUSIVE PRICE
    5230.00 NOK
    4978.83 NOK / 250g
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Estimated Shipment: 29-09-2026
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Beskrivning

Niclosamide ≥98%, Greenish-Yellow Powder

  • It is used to study the Wnt/Frizzled-1 signaling pathway.
  • It is used to inhibit the transcription and DNA binding of NF-κB in AML cells and to induce apoptosis.
  • It is effective against cestodes that infect humans.
  • Niclosamide uncouples oxidative phosphorylation in the tapeworm.
  • It inhibits mitochondrial oxidative phosphorylation of parasitic helminths.
  • It inhibits the NF-κB pathway in acute myelogenous leukemia (AML) cells.
  • Niclosamide inhibits the transcription and DNA binding of NF-κB.
  • It blocks tumor necrosis factor-induced IκBα phosphorylation, translocation of p65, and expression of NF-κB– regulated genes in AML cells. It increases ROS levels to induce apoptosis in AML cells.

Kemiska identifierare

CAS 50-65-7
Molecular Formula C13H8Cl2N2O4
Molecular Weight (g/mol) 327.12
MDL Number MFCD00057597
InChI Key RJMUSRYZPJIFPJ-UHFFFAOYSA-N
Synonym 2´,5-Dichloro-4-nitrosalicylanilide
IUPAC Name 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide
SMILES OC1=CC=C(Cl)C=C1C(=O)NC1=CC=C(C=C1Cl)[N+]([O-])=O

Specifikationer

Melting Point 225°C to 233°C
Color Green-yellow
Loss on Drying ≤0.5%
Quantity 250 g
UN Number UN3077
Beilstein 2820605
Solubility Information Soluble in methanol:acetone [1:1] (50mg/mL).
Vapor Pressure Very low at room temp
Produkttitel
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