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Myelin basic protein Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 10458-1-AP-20UL

Additional Details : Weight : 0.00010kg

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Product Code. 16886853

  • 1281.92 NOK / 20µL
Estimated Shipment: 22-12-2022
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Description

Description

10458-1-AP is capable of recognizing multiple isoforms of MBP.

The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called "Golli-MBP") that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes.
Specifications

Specifications

Myelin basic protein
Polyclonal
Unconjugated
MBP
MBP, Myelin A1 protein, Myelin basic protein
Rabbit
Antigen Affinity Chromatography
RUO
17196, 24547, 4155
-20°C
Liquid
Western Blot, Immunohistochemistry (Paraffin)
0.5 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
P02686, P02688, P04370
Mbp
Myelin basic protein Fusion Protein Ag0713
20 μL
Primary
Mouse, Rat, Human
Antibody
IgG
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