Invitrogen™ MTCH2 Polyclonal Antibody

Description

Immunogen sequence: VGYEPLPPTI GRNIFGRQVC QLPGLFSYAQ HIASIDGRRG LFTGLTPRLC SGVLGTVVHG KVLQHYQESD KGEELGPGNV QKEVSSSFDH VIKETTREMI ARSAATLITH PFHVITLRSM VQFIGRESKY CGLCDSIITI YREEGI; Positive Samples: HepG2, HeLa, 293T, HT-29, Mouse small intestine, Mouse brain, Mouse liver; Cellular Location: Mitochondrion inner membrane, Multi-pass membrane protein.

MTCH2 is a member of the mitochondrial carrier protein family that catalyze the exchange of substrates across the inner mitochondrial membrane and is targeted by Bid, a pro-apoptotic Bcl-2 family member, in response to apoptotic signals, suggesting that MTCH2 may play a key role in the mitochondrial apoptosis pathway. Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. The Bcl-2 family of proteins is comprised of critical regulators of apoptosis that can be divided into two classes: those that inhibit apoptosis and those that promote cell death.