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Proteintech MPP8 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Brand: Proteintech 16796-1-AP-20UL
Additional Details : Weight : 0.00010kg
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DescriptionHeterochromatin component that specifically recognizes and binds methylated ′Lys-9′ of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic repression. Mediates recruitment of the HUSH complex to H3K9me3 sites: the HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3. Binds H3K9me and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene. Mediates down-regulation of CDH1 expression.
|HSMPP8, M phase phosphoprotein 8, MPHOSPH8, MPP8, TWA3|
|Antigen Affinity Chromatography|
|290270, 54737, 75339|
|Western Blot, Immunoprecipitation|
|PBS with 50% glycerol and 0.02% sodium azide; pH 7.3|
|G3V8T1, Q3TYA6, Q99549|
|MPP8 Fusion Protein Ag10268|
|Mouse, Rat, Human|