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Invitrogen™ Mouse IL-17A, AOF Recombinant Protein
E. coli Recombinant Protein
2280.00 NOK - 40740.00 NOK
Specifications
Accession Number | Q62386 |
---|---|
For Use With (Application) | Control, ELISA, Functional Assay, Gel Shift, Western Blot |
Formulation | 10 mM sodium phosphate, 150 mM sodium sulfate with no preservative |
Gene ID (Entrez) | 16171 |
Molecular Weight (g/mol) | 15.1 kDa |
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
---|---|---|---|---|---|---|---|---|---|
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
17656575
|
Invitrogen™
RP87768 |
100 μg |
5780.00 NOK
100µg |
Estimated Shipment: 30-05-2024 Log in to see stock. |
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17666575
|
Invitrogen™
RP87770 |
1 mg |
40740.00 NOK
1mg |
Estimated Shipment: 30-05-2024 Log in to see stock. |
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17676575
|
Invitrogen™
RP87771 |
25 μg |
2280.00 NOK
25µg |
Estimated Shipment: 30-05-2024 Log in to see stock. |
Please sign in to purchase this item. Need a web account? Register with us today! | ||||
17686575
|
Invitrogen™
RP87772 |
500 μg |
25030.00 NOK
500µg |
Estimated Shipment: 30-05-2024 Log in to see stock. |
Please sign in to purchase this item. Need a web account? Register with us today! | ||||
Description
Interleukin-17A (IL-17A, CTLA-8) is a CD4+ T cell-derived cytokine that promotes inflammatory responses in cell lines and is elevated in rheumatoid arthritis, asthma, multiple sclerosis, psoriasis, and transplant rejection. IL-17A is a 32 kDa long, disulfide-linked homodimer consisting of 136 amino acids that is a member of a six-species family of proteins (IL-17A-17F) and signals through the IL-17 receptor (IL-17R/CDw217). High levels of IL-17A homodimer are produced by activated peripheral blood CD4+ T-cells, and IL-17A also enhances expression of the intracellular adhesion molecule-1 (ICAM-1) in human fibroblasts. In particular, human IL-17A also stimulates epithelial, endothelial, or fibroblastic cells to secrete IL-6, IL-8, G-CSF, and PGE2. In the presence of human IL-17A, fibroblasts can sustain the proliferation of CD34+ hematopoietic progenitors and induce maturation into neutrophils. Mouse, rat, and human IL-17A can induce IL-6 secretion in mouse stromal cells, indicating that all homologs can recognize the mouse receptor. IL-17A regulates the activities of NF-kappa B and mitogen-activated protein kinases, stimulates the expression of IL-6 and cyclooxygenase-2 (PTGS2/COX-2), and enhances the production of nitric oxide (NO).- Purity: >95% by SDS-Page
- Endotoxin Concentration: AX41 ≤EUs/μg
- Protein Length: 134 aa.
- Biological Activity: <5 ng/mL
- Molecular Weight: 15.1 kDa
- Animal Origin Free: Yes
Specifications
Q62386 | |
10 mM sodium phosphate, 150 mM sodium sulfate with no preservative | |
15.1 kDa | |
E. coli | |
RUO | |
IL17A | |
Unconjugated | |
Lyophilized |
Control, ELISA, Functional Assay, Gel Shift, Western Blot | |
16171 | |
Mouse IL-17 A, AOF | |
-20°C | |
BOS_21471; CTLA8; CTLA-8; Cytotoxic T-lymphocyte-associated antigen 8; cytotoxic T-lymphocyte-associated protein 8; il 17; IL17; IL-17; IL17A; IL-17 A; ILN; Interleukin; interleukin 17; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8); interleukin 17 A; interleukin 17 A-like; interleukin-17; Interleukin17A; Interleukin-17 A; LOC100339322; R-IL-17-A | |
Mouse | |
Recombinant | |
>95% |