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ACROBiosystems Mouse HMGB1 Protein, His Tag

Brand:  ACROBiosystems HM1-M52H6-1mg

Additional Details : Weight : 0.00010kg

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Product Code. 16447639

  • 36221.90 NOK / 1mg
Estimated Shipment: 23-01-2023
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Description

Description

High-mobility group protein B1 (HMGB1) is also known as high-mobility group protein 1 (HMG-1) and amphoterin, is a member of the HMGB family consisting of three members, HMGB1, HMGB2 and HMGB3. HMGB1 is a non-histone architectural chromosomal protein ubiquitously present in all vertebrate nuclei and binds double-stranded DNA without sequence specificity. The mechanism of inflammation and damage is binding to TLR4, which mediates HMGB1-dependent activation of macrophage cytokine release. This positions HMGB1 at the intersection of sterile and infectious inflammatory responses. HMGB1 has been studied as a DNA vaccine adjuvant and a target for cancer therapy.

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 26.8 kDa. The protein migrates as 33 kDa and 35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Specifications

Specifications

NP_034569.1
26.8 kDa
1 mg
Met 1 - Glu 215
HMGB1,HMG1,HMG3,SBP-1
Unconjugated
PBS, pH7.4
HEK293
Mouse
Powder
>90% as determined by SDS-PAGE
Mouse HMGB1, His Tag (HM1-M52H6) is expressed from human 293 cells (HEK293). It contains AA Met 1 - Glu 215 (Accession # P63158-1).
-20°C
HMGB1
His Tag
Less than 1.0 EU / µg by the LAL method.
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