Invitrogen™ Mouse FLIP Synthetic Peptide

Description

FLIP Synthetic Peptide, PEP-0013, from Invitrogen.

FLIP (CFLAR) is an apoptosis regulator protein which functions as a crucial link between cell survival and cell death pathways in mammalian cells. It acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity. This peptide corresponds to 17 amino acids near the carboxy terminus of mouse FLIP.PEP-0013 can be used as a blocking peptide with polyclonal antibody PA5-19881.