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Gibco™ Mouse EGF Native Protein

Product Code. 11514516
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Quantity:
100 μg
Unit Size:
100µg
Product Code. Quantity unitSize
11514516 100 μg 100µg
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Product Code. 11514516

Brand: Gibco™ 53003018

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Description

Native Protein

Reconstitution: Reconstituted EGF should be aliquoted and stored in polypropylene vials and is stable at -5°C to -20°C for up to two months. Avoid repeated freezing and thawing. Stability of dilute solutions of EGF may be prolonged by addition of bovine serum albumin to a final concentration of 1.0%. This natural preparation of murine epidermal growth factor (EGF) was isolated from male mouse submaxillary glands. It is not sterile as provided.

EGF (Epidermal growth factor) exerts its actions by binding to the EGF Receptor, a 170 kDa protein kinase. Activation of EGFR initiates diverse cellular pathways in response to toxic environmental stimuli, or to EGF binding to the receptor, the EGFR forms homo- or heterodimers with other family members. Each dimeric receptor complex initiates a distinct signaling pathway by recruiting different Src homology 2 (SH2) containing effector proteins. EGF is far and wide expressed in kidney, cerebrum, prostrate and salivary glands. EGF acts as a potent mitogenic factor and the phosphorylated receptor recruits adapter proteins like GRB2 that activates complex downstream signaling cascades. EGF activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STAT modules. Research studies suggest the protein may also play important role in activating the NF-kappa-B signaling cascade. Defects in the EGGF gene are the cause of hypomagnesemia type 4 and dysregulation has been associated with the growth and progression of certain cancers.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number P01132
For Use With (Application) Bioactivity
Formulation Protein with no preservative
Gene ID (Entrez) 13645
Molecular Weight (g/mol) 6 kDa
Name Mouse EGF
Purification Method Purified
Quantity 100 μg
Storage Requirements -20°C
Regulatory Status RUO
Gene Alias AI790464; beta-urogastrone; EGF; Epidermal growth factor; epidermal growth factor (beta-urogastrone); epidermal growth factor precursor; H-EGF; HOMG4; Pro-epidermal growth factor; Pro-epidermal growth factor precursor (EGF); sb:eu639; URG; Urogastrone
Common Name EGF
Gene Symbol EGF
Product Type Protein
Conjugate Unconjugated
Species Mouse
Content And Storage -20°C
Shipping Condition Approved for shipment at Room Temperature or on Wet or Dry Ice
Protein Family Growth Factors & Receptors
Protein Form Native, Ligand
Form Lyophilized
Protein Subtype EGF (Epidermal Growth Factor)
Research Category Neurobiology, Stem Cell Research, Differentiation, Oncology
Purity or Quality Grade >95% by SDS-PAGE
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