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MKC8866, MedChemExpress

Product Code. 16473938
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Product Code. Quantity unitSize
16473938 10 mg 10mg
16492916 25 mg 25mg
16456657 5 mg 5mg
16440297 50 mg 50mg
16414966 100 mg 100mg
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Product Code. 16473938

Brand: Medchem Express HY104040

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Description

MedChemExpress MKC8866, a salicylaldehyde analog, is a potent, selective IRE1 RNase inhibitor with an IC50 of 0.29 μM in human vitro.

MKC8866 strongly inhibits Dithiothreitol-induced X-box-binding protein 1-spliced (XBP1s) expression with an EC50 of 0.52 μM and unstresses RPMI 8226 cells with an IC50 of 0.14 μM. MKC8866 inhibits IRE1 RNase in breast cancer cells leading to the decreased production of pro-tumorigenic factors and it can inhibits prostate cancer (PCa) tumor growth.

Specifications

Chemical Name or Material MKC8866
CAS 1338934-59-0
Color Yellow
Purity Grade Notes Research
Molecular Formula C18H19NO7
Quantity 10 mg
Solubility Information DMSO : 16.67 mg/mL (46.13 mM; Need ultrasonic)
SMILES O=CC1=C(O2)C(C(C)=C(CC(N3CCOCC3)=O)C2=O)=CC(OC)=C1O
Molecular Weight (g/mol) 361.35
Formula Weight 361.35
Percent Purity 98.22%
Grade Research
Physical Form Powder
For Use With (Application) Cancer-programmed cell death
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Research purposes only

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