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Methotrexate, Fisher BioReagents

Product Code. 10705304
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Quantity:
10 mg
100 mg
Packaging:
Amber Glass
Unit Size:
100mg
10mg
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Product Code. Quantity Packaging unitSize
10705304 10 mg Amber Glass 10mg
10204923 100 mg Amber Glass 100mg
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Product Code. 10705304 Supplier Fisher BioReagents Supplier No. BP266510
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Description

  • Inhibitor of DNA and RNA synthesis
  • Inhibits the enzyme responsible for synthesizing the folic acid derivative that is necessary for purine and pyrimidine synthesis
  • The lack of purines and pyrimidines  impacts the synthesis of DNA, RNA, and proteins
  • Referenced for use in antitumor studies and other studies of biological pathways
  • Intended for research use only
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 59-05-2
Molecular Formula C20H22N8O5
Molecular Weight (g/mol) 454.447
InChI Key FBOZXECLQNJBKD-ZDUSSCGKSA-N
Synonym methotrexate, abitrexate, rheumatrex, amethopterin, mexate, metatrexan, hdmtx, trexall, methylaminopterinum, antifolan
PubChem CID 126941
ChEBI CHEBI:44185
IUPAC Name (2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid
SMILES CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O

Specifications

Decomposition Information >195°C
Melting Point 195°C
Color Yellow
Ignition Residue 0.1% max.
Assay Percent Range 98.0 to 102.0 %
Packaging Amber Glass
Quantity 10 mg
Merck Index 15, 6057
Specific Rotation +19.0 to +24.0° (+ or -)
Formula Weight 454.44
Percent Purity 98.0 to 102.0%
Physical Form Powder or Solid
Chemical Name or Material Methotrexate
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Safety and Handling

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Product Identifier
  • Methotrexate
 Signal Word
  • Danger
 Hazard Category
  • Acute toxicity Category 3
  • Serious eye damage/eye irritation Category 2
  • Germ cell mutagenicity Category 1B
  • Reproductive toxicity Category 1B
  • Skin corrosion/irritation Category 2
  • Specific target organ toxicity Category 3
 Hazard Statement
  • H340-May cause genetic defects.
  • H360FD-May damage fertility. May damage the unborn child.
  • H315-Causes skin irritation.
  • H319-Causes serious eye irritation.
  • H335-May cause respiratory irritation.
  • H301-Toxic if swallowed.
 Precautionary Statement
  • P280-Wear protective gloves/protective clothing/eye protection/face protection.
  • P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P308+P313-IF exposed or concerned: Get medical advice/attention.
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