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Mesothelin Monoclonal Antibody (C6), Invitrogen™

Mouse Monoclonal Antibody

Brand:  Invitrogen MA543663

Additional Details : Weight : 0.01000kg

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Product Code. 17674116

  • 4120.00 NOK / 100µL
Estimated Shipment: 21-06-2024
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Description

Description

Originally identified as a differentiation antigen of mesotheliomas, ovarian cystadenocarcinomas, and pancreatic adenocarcinomas, Mesothelin is a glycosylphosphatidylinositol (GPI)-anchored, cell-surface glycoprotein predominantly secreted by cells of the mesothelium. Although Mesothelin is expressed at restricted levels by normal mesothelial cells of the pleural,pericardial, and peritoneal membranes, aberrant expression has been documented in the aforementioned cancers, as well as in endometriod uterine adenocarcinomas and squamous cell carcinomas of the esophagus, stomach, lung, and cervix. Proteolytic cleavage of Mesothelin yields a soluble, polypeptide fragment designated megakaryocyte potentiating factor (MPF) based on its ability to stimulate megakaryocyte colony-forming activity of murine interleukin-3 in murine bone marrow cell cultures. Originally isolated from the HPC-Y5 pancreatic cell line, MPF has been suggested to play a role in the proliferation and differentiation of megakaryoctyes, and the regulation of resultant platelet production. While the biological functions of both Mesothelin and MPF remain speculative, high-levels of expression in cancerous tissues compared to limited distribution in normal tissues strongly suggests their involvement in tumorigenesis. Both have been demonstrated to promote tumor cell proliferation, migration,anchorage-independent growth, and tumor progression; demonstrating their involvement in heterotypic cell adhesion and the metastatic spread of cancer.
Specifications

Specifications

Mesothelin
Monoclonal
1 mg/mL
PBS with 50% glycerol and 0.05% ProClin 300
Q13421
MSLN
Glu296-Ser606 (Accession Q13421), with N-terminal His Tag
100 μL
Primary
Human
Antibody
IgG1 κ
Western Blot
C6
Unconjugated
MSLN
CAK1; CAK1 antigen; megakaryocyte potentiating factor; Megakaryocyte-potentiating factor; Mes; Mesothelin; Mesothelin, cleaved form; MPF; MSLN; Pre-pro-megakaryocyte-potentiating factor; SMR; SMRP; soluble MPF mesothelin related protein
Mouse
Protein A/G
RUO
10232
-20°C
Liquid
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