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Description
The antibody recognizes the N-term of LRWD1.
Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 in a cooperative manner with DNA methylation. Required for silencing of major satellite repeats. May be important ORC2, ORC3 and ORC4 stability.
Specifications
Specifications
| Antigen | LRWD1 |
| Applications | Western Blot, Immunoprecipitation |
| Classification | Polyclonal |
| Concentration | 0.35 mg/mL |
| Conjugate | Unconjugated |
| Formulation | PBS with 50% glycerol and 0.1% sodium azide; pH 7.3 |
| Gene | LRWD1 |
| Gene Accession No. | Q8BUI3, Q9UFC0 |
| Gene Alias | LRWD1 |
| Gene Symbols | Lrwd1 |
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Product Title
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