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LRRTM3 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 27003-1-AP-20UL

Additional Details : Weight : 0.00010kg

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Product Code. 16885315

  • 1281.92 NOK / 20µL
Estimated Shipment: 15-12-2022
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Description

Description

The Leucine-rich repeat transmembrane neuronal proteins (LRRTMs) are differentially expressed in the nervous system and were recently found to instruct presynaptic and mediate postsynaptic glutamatergic differentiation, with LRRTM1 and LRRTM2 most potent at inducing presynaptic differentiation. Recent evidence suggests that LRRTM3 promotes the processing of amyloid-precursor protein (APP) by the beta-secretase BACE, leading to the proteolytic production of the A-beta42 peptide that is the main component of amyloid plaques. Furthermore, LRRTM3 maps to a region of chromosome 10 linked to both late-onset Alzheimer′s disease (AD) and elevated plasma A-beta42 levels, suggesting that LRRTM3 is a functional and positional candidate gene for AD.
Specifications

Specifications

LRRTM3
Polyclonal
Unconjugated
LRRTM3
LRRTM3
Rabbit
Antigen Affinity Chromatography
RUO
216028, 294380, 347731
-20°C
Liquid
Immunohistochemistry (Paraffin), Western Blot
0.4 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
D3ZAL8, Q86VH5, Q8BZ81
LRRTM3
LRRTM3 Fusion Protein Ag25452
20 μL
Primary
Mouse, Human, Rat
Antibody
IgG
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