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Invitrogen™ LRRK2 [G2019S] Recombinant Protein

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene, which codes for a multidomain protein kinase, are considered the most common genetic cause of late-onset autosomal-dominant Parkinson's disease.

Brand:  Invitrogen™ A15200

Additional Details : Weight : 0.00900kg

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Product Code. 15310861

  • 4000.00 NOK / 10µg
Estimated Shipment: 15-05-2024
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Description

Description

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene, which codes for a multidomain protein kinase, are considered the most common genetic cause of late-onset autosomal-dominant Parkinson's disease. This full-length, purified and active LRRK2 G2019S mutant protein may be useful in research to better understand the most common Parkinson's disease-relevant mutant, as well as to explore the mechanisms underlying the disease.

  • Increase disease relevance by interrogating a purified and active full-length LRRK2 protein
  • Uncover novel compounds or hits specific to the full-length form
  • Advance Parkinson's research using the full-length protein and validated assays

    Related Links:
  • LRRK2 tools for advancing Parkinson's disease research
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  • Specifications

    Specifications

    NP_940980.3
    288 kDa
    AURA17, DARDARIN, PARK8, RIPK7, ROCO2
    Human
    Store at -68 to -85°C. Aliquot at first use to avoid multiple freeze-thaws. If properly stored, this product is guaranteed for 6 months from date of purchase.

    Suspended in: 50 mM Tris (pH 7.5), 150 mM NaCl, 0.5 mM EDTA, 0.02% Triton™X–100, 2 mM DTT, and 50% glycerol.
    Kinases & Inhibitors
    Liquid
    Kinase Assay
    10 μg
    LRRK Kinase Family
    DYKDDDDK
    Mammalian
    Recombinant, Full Length, Mutant
    Neurobiology
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