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  6. LIN28 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

LIN28 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Product Code. 16838993 Shop All Proteintech Products
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150 μL
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16838993 20 μL 20µL
16828993 150 μL 150µL
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Product Code. 16838993 Supplier Proteintech Supplier No. 117241AP20UL

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Description

Rabbit Polyclonal Antibody

This antibody is a rabbit polyclonal antibody raised against full length LIN28 of human origin. The calculated molecular weight of LIN28 is 23 kDa, but the modified LIN28 is about 28 kDa.

Lin28 is a transcription factor that was first identified through its key role in the pathway of developmental timing in C. elegans. The role of Lin28 in development suggested that it might be useful in the creation of stem cells that might be beneficial in cell replacement therapies in the treatment of several degenerative diseases. Artificial stem cells, termed induced pluripotent stem (iPS) cells, can be created by expressing Lin28 in addition to the transcription factors POU5F1, Sox2, and NANOG in mouse fibroblasts. More recently, experiments have demonstrated that iPS cells could be generated using expression plasmids expressing Lin28, Sox2, POU5F1 and c-Myc, eliminating the need for virus introduction, thereby addressing a safety concern for potential use of iPS cells in regenerative medicine.

Specifications

Antigen LIN28
Applications Immunohistochemistry (Paraffin), Western Blot, Immunoprecipitation, Immunofluorescence, Immunocytochemistry
Classification Polyclonal
Concentration 0.31 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Gene LIN28A
Gene Accession No. Q8K3Y3, Q9H9Z2
Gene Alias CSDD1, LIN 28, lin 28 homolog (C. elegans), Lin 28A, LIN28, Lin28A, Protein lin 28 homolog A, ZCCHC1
Gene Symbols Lin28a
Host Species Rabbit
Immunogen LIN28 Fusion Protein Ag2312
Purification Method Antigen Affinity Chromatography
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 500562, 79727, 83557
Target Species Rat, Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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