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Leptin Rabbit anti-Human, Mouse, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 17436-1-AP-150UL

Additional Details : Weight : 0.00010kg

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Product Code. 16887324

  • 3468.15 NOK / 150µL
Estimated Shipment: 16-12-2022
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Description

Description

Leptin is a 167 amino acid long protein hormone with important effects in regulating body weight, metabolism and reproductive function. Leptin is approximately 16 kDa in mass and encoded by the obese (ob) gene. Leptin is expressed predomitly by adipocytes, which fits with the idea that body weight is sensed as the total mass of fat in the body. Smaller amounts of leptin are also secreted by cells in the epithelium of the stomach and in the placenta. Leptin receptors are highly expressed in areas of the hypothalamus known to be important in regulating body weight, as well as in T lymphocytes and vascular endothelial cells. Leptin′s effects on body weight are mediated through effects on hypothalamic centers that control feeding behavior and hunger, body temperature and energy expenditure. Leptin is involved in regulating food intake, energy expenditure, and adiposity through hypothalamic leptin receptors. Leptin promotes hematopoiesis, angiogenesis, wound healing, inflammation, immune responses, influences pubertal development and fetal growth. Studies have investigated the role of leptin in obesity, anorexia nervosa, insulin resistance, and hypertension. Leptin also has thermogenic actions and regulates enzymes of fatty acid oxidation. Severe hereditary obesity in rodents and humans can be caused by defects in leptin production.
Specifications

Specifications

Leptin
Polyclonal
Unconjugated
LEP
LEP, leptin, OB, Obese protein, Obesity factor, OBS
Rabbit
Antigen Affinity Chromatography
RUO
16846, 3952
-20°C
Liquid
Immunohistochemistry (Paraffin), Immunofluorescence, Immunocytochemistry
0.13 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
P41159, P41160
Lep
Leptin Fusion Protein Ag11507
150 μL
Primary
Mouse, Human
Antibody
IgG
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