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  8. L(+)-Amethopterin hydrate, 99%

L(+)-Amethopterin hydrate, 99%

Product Code. 10491631 Shop All Thermo Scientific Chemicals Products
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100 mg
500 mg
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Unit Size:
100mg
25mg
500mg
Product Code. Quantity Packaging unitSize
10491631 100 mg Glass Bottle 100mg
10002690 25 mg Glass Bottle 25mg
10066203 500 mg Glass Bottle 500mg
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Product Code. 10491631

Brand: Thermo Scientific Acros 208101000

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Description

L(+)-Amethopterin hydrate, CAS # 133073-73-1, is an effective inhibitor of dihydrofolate reductase, which may have anti-tumor activity. | CAS: 133073-73-1 | C20H22N8O5 | 454.45 g/mol

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

  • L(+)-Amethopterin hydrate, is a potent inhibitor of dihydrofolate reductase
  • It has tumoricidal activity

Applications

  • L(+)-Amethopterin hydrate is an inhibitor of dihydrofolate reductase
  • It can be used in anti-tumor studies
  • It is a cell cycle arrest agent, which can inhibit synthesis of DNA, RNA, and proteins
  • It can also inhibit production of pro-inflammatory cytokines
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 133073-73-1
Molecular Formula C20H22N8O5
Molecular Weight (g/mol) 454.45
MDL Number MFCD00150847
InChI Key FBOZXECLQNJBKD-UGPWUYPHNA-N
Synonym l +-amethopterin dihydrate, methotrexate dihydrate, dihydrate methotrexate, 2s-2-4-2,4-diaminopteridin-6-yl methyl methylamino phenyl carbonylamino pentanedioic acid, hydrate, hydrate
PubChem CID 45157423
IUPAC Name (2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid;dihydrate
SMILES CN(CC1=CN=C2N=C(N)N=C(N)C2=N1)C1=CC=C(C=C1)C(=O)N[C@@H](CCC(O)=O)C(O)=O

Specifications

Melting Point 195°C
Color Yellow to Orange
Infrared Spectrum Authentic
Assay Percent Range 98.5% min. (HPLC)
Packaging Glass Bottle
Quantity 100 mg
Merck Index 14, 5985
Specific Rotation + 21.5
Solubility Information Solubility in water: insoluble in water. Other solubilities: insoluble in alcohol,chloroform,ether,slightly soluble in dilute hydrochloric acid,soluble in dilute solutions of alkali hydroxides a
Formula Weight 454.44
Percent Purity 99%
Physical Form Crystalline Powder
Chemical Name or Material L(+)-Amethopterin hydrate
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Safety and Handling

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Product Identifier
  • L(+)-Amethopterin hydrate
 Signal Word
  • Danger
 Hazard Category
  • Acute toxicity Category 3
  • Germ cell mutagenicity Category 1B
  • Reproductive toxicity Category 1A
 Hazard Statement
  • H360D-May damage the unborn child.
  • H340-May cause genetic defects.
  • H301-Toxic if swallowed.
 Precautionary Statement
  • P201-Obtain special instructions before use.
  • P301+P310-IF SWALLOWED: Immediately call a POISON CENTER/doctor /
  • P308+P313-IF exposed or concerned: Get medical advice/attention.
SDS

RUO – Research Use Only

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