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  6. KIAA0652 Mouse anti-Human, Mouse, Porcine, Rat, Clone: 1C3A7, Proteintech

KIAA0652 Mouse anti-Human, Mouse, Porcine, Rat, Clone: 1C3A7, Proteintech

Product Code. 16888835 Shop All Proteintech Products
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Quantity:
150 μL
20 μL
Unit Size:
150µL
20µL
Product Code. Quantity unitSize
16888835 20 μL 20µL
16878835 150 μL 150µL
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Product Code. 16888835

Brand: Proteintech 667081IG20UL

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Description

Mouse Monoclonal Antibody

Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein ATG1. ATG13 forms a complex with ULK1 and ULK2, the mammalian homologs of ATG1, and with FIP200. This complex is a target of TOR phosphorylation under normal conditions; inhibition of TOR by rapamycin or leucine deprivation leads to dephosphorylation of ATG13, ULK1 and ULK2, which then leads to autophagy. Knockdown of ATG13 inhibits autophagosome formation.

Specifications

Antigen KIAA0652
Applications Immunohistochemistry (Paraffin), Western Blot, Immunofluorescence, Immunocytochemistry
Classification Monoclonal
Clone 1C3A7
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Gene ATG13
Gene Accession No. O75143, Q91YI1
Gene Alias ATG13, Autophagy related protein 13, FLJ20698, KIAA0652
Gene Symbols Atg13
Host Species Mouse
Immunogen KIAA0652 Fusion Protein Ag12968
Purification Method Protein G
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100516128, 362164, 51897, 9776
Target Species Mouse, Human, Pig, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG1
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