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Description
- It is a broad spectrum aminoglycoside-antibiotic derived from Streptomyces kanamyceticus.
- It is used as an additive in culture media for the isolation of group D streptococci on Kanamycin Esculin Azide Agar and for selection of transformed plant cells containing the neomycin phosphotransferase on a kanamycin-medium.
- Kanamycin sulfate can also be used as a selection agent for cells transformed with kanamycin B resistance gene.
- Kanamycin sulfate is an antimicrobial agent effective against Gram-negative and Gram-positive bacteria and mycoplasma.
- It binds to the 70S ribosomal subunit, inhibits translocation, and elicits miscoding.
- Cross-resistance occurs between kanamycin and neomycin, framycetin, and paromomycin, and partial cross-resistance has been reported between kanamycin and streptomycin. Aminoglycosidemodifying enzymes (acetyltransferase, phosphotransferase, nucleotidyltransferase) alter the antibiotic, preventing its interaction with ribosomes.
Specifications
Specifications
| Physical Form | Powder |
| pH | 6.5 to 8.5 (1% solution) |
| Melting Point | >250°C |
| Loss on Drying | <4% |
| Potency | >750 µg/mg |
| Color | White |
| Quantity | 25 g |
| Solubility Information | Soluble in 10-50mg/mL of Water |
| Grade | USP |
Product Title
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