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JAK1 Mouse anti-Human, Rat, Clone: 3H7A8, Proteintech

Mouse Monoclonal Antibody

Brand:  Proteintech 66466-1-IG-150UL

Additional Details : Weight : 0.00010kg

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Product Code. 16888365

  • 3468.15 NOK / 150µL
Estimated Shipment: 14-12-2022
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Description

Description

JAK1 (Janus kinase 1) belongs to the family of non-receptor Janus tyrosine kinases, which regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK1. JAK1 then phosphorylates proximal Stat factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regulate transcription. Upon ligand binding, JAK1 undergoes tyrosine phosphorylation and catalytic activation in an interdependent manner. Phosphorylation of tyrosine residues at positions 1022 and 1023 is believed to function in the activation of catalytic events.
Specifications

Specifications

JAK1
Monoclonal
1 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
P23458
JAK1
JAK1 Fusion Protein Ag17940
150 μL
Primary
Rat, Human
Antibody
IgG2b
Western Blot, Immunohistochemistry (Paraffin)
3H7A8
Unconjugated
JAK1
JAK 1, JAK1, JAK1A, JAK1B, Janus kinase 1, JTK3, Tyrosine protein kinase JAK1
Mouse
Protein A
RUO
3716, 84598
-20°C
Liquid
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Documents
Certificates
Special Offers

Special Offers