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Description
Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. The protein encoded by this gene interacts with atrophin-1. This encoded protein is a closely related member of the NEDD4-like protein family. This family of proteins are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. This encoded protein contains four tandem WW domains and a HECT domain. It can act as a transcriptional corepressor of p45/NFE2 and may participate in the regulation of immune responses by modifying Notch-mediated signaling. It is highly similar to the mouse Itch protein, which has been implicated in the regulation and differentiation of erythroid and lymphoid cells.
Specifications
Specifications
| Antigen | ITCH |
| Applications | Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot |
| Classification | Polyclonal |
| Concentration | 0.23 mg/mL |
| Conjugate | Unconjugated |
| Formulation | PBS with 50% glycerol and 0.1% sodium azide; pH 7.3 |
| Gene | ITCH |
| Gene Accession No. | Q8C863, Q96J02 |
| Gene Alias | AIF4, AIP4, ITCH, NAPP1, NFE2 associated polypeptide 1 |
| Gene Symbols | ITCH |
| Show More |
Product Title
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