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Invitrogen™ Integrin beta 7 Polyclonal Antibody
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Product Code. 17209533 Shop All Thermo Scientific Products
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Quantity:
100 μL
Unit Size:
100µL
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17209533 100 μL 100µL
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Product Code. 17209533 Supplier Invitrogen™ Supplier No. PA5117030

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Description

Rabbit Polyclonal Antibody

Positive Samples: HT-29, THP-1, LO2, Mouse lung, Mouse thymus Immunogen sequence: MVALPMVLVL LLVLSRGESE LDAKIPSTGD ATEWRNPHLS MLGSCQPAPS CQKCILSHPS CAWCKQLNFT ASGEAEARRC ARREELLARG CPLEELEEPR GQQEVLQDQP LSQGARGEGA TQLAPQRVRV TLRPGEPQQL.

Integrin beta 7 associates with integrin alpha 4 (CD49d) to form the alpha 4 beta 7 integrin LPAM-1, expressed on intraepithelial lymphocytes. It also associates with alpha E (CD103) to form the alpha E beta 7 integrin HML-1, expressed on T cells adjacent to mucosal epithelium and intraepithelial lymphocytes. Ligands for LPAM-1 include VCAM-1 (CD106), MAdCAM-1 and fibronectin, while the ligand of HML-1 is E-cadherin (CD324). Integrin beta 7 plays an important role in the adhesion of leukocytes to endothelial cells promoting the transmigration of leukocytes to extravascular spaces during the inflammatory response.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Integrin beta 7
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 0.26 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene ITGB7
Gene Accession No. P26010, P26011
Gene Alias Gut homing receptor beta subunit; integrin beta 7; integrin beta 7 subunit; integrin beta-7; Integrin beta-P; integrin subunit beta 7; integrin, beta 7; ITGB7; Ly69; M290 IEL antigen
Gene Symbols ITGB7
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human ITGB7 (NP_0008801).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16421, 3695
Target Species Human, Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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