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  6. Integrin alpha-4 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Integrin alpha-4 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Product Code. 16899144 Shop All Proteintech Products
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Quantity:
150 μL
20 μL
Unit Size:
150µL
20µL
Product Code. Quantity unitSize
16899144 20 μL 20µL
16889144 150 μL 150µL
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Product Code. 16899144

Brand: Proteintech 196761AP20UL

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Description

Rabbit Polyclonal Antibody

The integrin alpha 4 (also known as CD49d and ITGA4) belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha and beta chains. The alpha 4 chain associates with either the beta1 or beta7 chain. It has been demonstrated that the putative ligand-binding sites of both integrin alpha4 beta1 and alpha4 beta7 is located on the alpha4 chain. These ligands included Madcam, VCAM, and fibronectin. Madcam is known as the principal ligand for integrin alpha4 beta7. It was also demonstrated that the HIV-1 envelope can mimic Madcam by binding to and signaling though integrin alpha4 beta7, the gut mucosal homing receptor for peripheral T cells.

Specifications

Antigen Integrin alpha-4
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.35 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene ITGA4
Gene Accession No. P13612, Q00651
Gene Alias CD49D, IA4, Integrin alpha 4, Integrin alpha IV, ITGA4, VLA 4 subunit alpha
Gene Symbols ITGA4
Host Species Rabbit
Immunogen Peptide
Purification Method Antigen Affinity Chromatography
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16401, 311144, 3676
Target Species Mouse, Human, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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