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IL-23 p19 Monoclonal Antibody (HNU2319), Functional Grade, eBioscience™, Invitrogen™
Mouse Monoclonal Antibody
Marca: Affymetrix eBioscience 16-5236-025
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Descrizione
The HNU2319 MAb is specific to the p19 subunit of human IL-23, a heterodimeric cytokine made up of two covalently linked subunits, p40 and p19. It is closely related to IL-12, with which it shares the p40 subunit. Dendritic cells and macrophages produce IL-23 in response to TLR2, TLR4, and TLR8 ligands, as well as the beta-glucan receptor Dectin-1. Human IL-23 induces proliferation of memory T cells and induces moderate levels of IFN-gamma production by naive and memory T cells, as compared to IL-12. In contrast, the mouse IL-23 biological activities are more distinctly different than those of mouse IL-12 suggesting the signaling or response elements (receptors) differ between species. The IL-23 receptor is also heterodimeric and shares the IL-12Rbeta1 chain with IL-12, while the IL-23R chain is unique to IL-23. Signaling occurs through the Jak/STAT pathway and results in RORgammat expression, which drives the differentiation of CD4^+ T-cells towards the Th17 phenotype. The MAb HNU2319 neutralizes the bioactivity of IL-23 without affecting IL-12.
IL-23 p19 Monoclonal antibody specifically detects IL-23 p19 in Human samples. It is validated for Functional Assay, Neutralization
Specifica
| IL-23 p19 | |
| Monoclonal | |
| 1 mg/mL | |
| PBS with no preservative; pH 7.2 | |
| Q9NPF7 | |
| Mouse | |
| 25 mg | |
| Primary | |
| Human | |
| Antibody | |
| IgG1 κ |
| Functional Assay, Neutralization | |
| HNU2319 | |
| Functional Grade | |
| IL23A | |
| il 23; IL 23 A; IL12B; Il-12b; Il12p40; Il-12p40; il23; IL-23; IL-23 subunit alpha; Il23a; IL-23A; IL-23-A; IL23P19; IL-23p19; ILN; Interleukin; interleukin 12B; interleukin 23 p19 subunit; interleukin 23 subunit alpha; Interleukin 23, alpha subunit p19; interleukin-23 subunit alpha; Interleukin-23 subunit p19; interleukin-six, G-CSF related factor; JKA3 induced upon T-cell activation; MGC79388; P19; p40; RP23-388G23.1; SGRF; UNQ2498/PRO5798 | |
| Affinity chromatography | |
| RUO | |
| 51561 | |
| 4° C | |
| Liquid |
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