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IL-1 beta, clone: CRM56, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-7018-85

Additional Details : Weight : 0.01000kg

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Product Code. 15287977

  • 1916.00 NOK / 500µg


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Description

Description

2 μm post-manufacturing filtered. Interleukin-1 beta (IL-1 beta) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta is synthesized in response to inflammatory stimuli as a 31 kDa inactive pro-form that accumulates in the cytosol. Cleavage of pro-IL-1 beta into the active 17 kDa protein requires the activation of inflammasomes, which are multi-protein complexes that respond to pathogens, stress conditions, and other danger signals. Inflammasome activation triggers the processing of the caspase-1 precursor into its active form, which in turn cleaves pro-IL-1 beta. IL-1 beta lacks a signal sequence peptide for classical ER/Golgi pathway and is secreted alongside caspase-1 via an alternate and incompletely understood mechanism. Although IL-1 beta is most often secreted in its active form, secretion of the uncleaved protein may be detectable under some biological conditions. IL-1 beta signals through two receptors, IL-1RI and IL-1RII, both of which are shared with IL-1 alpha. IL-1 beta activity can be moderated by IL-1 Receptor Antagonist (IL-1RA), a protein produced by many cell types that blocks receptor binding through competitive inhibition. IL-1 beta play an important role in innate host defense by triggering the production of other proinflammatory cytokines in target cells and initiating acute-phase responses to infection and injury. Elevated levels of IL-1 beta have been associated with many chronic inflammatory conditions IL-1 beta neutralizing antibodies potential therapeutic value.
Specifications

Specifications

IL-1 beta
Monoclonal
0.5 mg/mL
PBS with 0.09% sodium azide; pH 7.2
P01584
Interleukin-1 beta, Catabolin, IL1B
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Human
ELISA, Flow Cytometry, Functional Assay, Neutralization
CRM56
Unconjugated
IL1B
Liquid
IL1B
IgG1
500 μg
4° C
Primary
3553
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