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Description
Intercellular adhesion molecule-1 (ICAM-1, CD54) is an integral membrane protein, a member of the immunoglobulin superfamily, and a ligand for lymphocyte function-associated (LFA) antigens, a beta 2 leukocyte integrin. The normal function of human ICAM-1 is to provide adhesion between endothelial cells and leukocytes after injury or stress. ICAM-1 binds to leukocyte function-associated antigen (LFA-1) or macrophage-1 antigen (Mac-1). It is found on leukocytes, fibroblasts, epithelial cells and endothelial cells and its expression is regulated by inflammatory cytokines. ICAM-1 has a tissue distribution similar to that of the major histocompatibility complex class II antigens and is likely to play a role in inflammatory responses.
Specifications
Specifications
| Antigen | ICAM-1 |
| Applications | Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot |
| Classification | Monoclonal |
| Clone | 2F9A8 |
| Concentration | 0.7 mg/mL |
| Conjugate | Unconjugated |
| Formulation | PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 |
| Gene | ICAM1 |
| Gene Accession No. | P05362 |
| Gene Alias | BB2, CD54, ICAM 1, ICAM1, ICAM-1, P3.58 |
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Product Title
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