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Description
This gene encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluro, one of the major glycosaminoglycans of the extracellular matrix. Hyaluro is thought to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. Multiple transcript variants encoding different isoforms have been found for this gene.
Specifications
Specifications
| Antigen | HYAL1 |
| Applications | Western Blot |
| Classification | Monoclonal |
| Clone | 1B8B5 |
| Concentration | 1 mg/mL |
| Conjugate | Unconjugated |
| Formulation | PBS with 50% glycerol and 0.1% sodium azide; pH 7.3 |
| Gene | HYAL1 |
| Gene Accession No. | Q12794, Q76HN1 |
| Gene Alias | HYAL 1, HYAL1, Hyaluronidase 1, hyaluronoglucosaminidase 1, LuCa 1, LUCA1, Lung carcinoma protein 1, NAT6 |
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