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Proteintech HumanKine™ recombinant human IL-5 protein

Product Code. p-7225804 Shop All Proteintech Products
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Quantity:
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100 μg
1000 μg
Unit Size:
1000µg
100µg
10µg
Product Code. Quantity unitSize
17640097 1000 μg 1000µg
17650097 100 μg 100µg
17660097 10 μg 10µg
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Product Code. 17640097

Brand: Proteintech HZ13241000UG

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Description

HumanKine™ recombinant protein

IL-5 is a 4-α-helix, pleiotropic cytokine that regulates the activities of B cells, eosinophils, and basophils. It is produced mostly by CD4+ T cells, eosinophils, and basophils, and signals through its specific receptor (IL-5R) on target cells to activate downstream JAK/STAT, Btk, and Ras/ERk pathways. Due to its pleiotropic effects, IL-5 plays a role in both innate and adaptive immune responses. It is a strong promoter of eosinophil differentiation, migration, maturation, and survival. Additionally, IL-5 is also capable of stimulating activated B cells to differentiate into antibody-secreting cells. Elevated IL-5 levels are strongly correlated with eosinophilia, which is a hallmark feature of allergy, asthma, and hypersensitivity (PMID: 21986312, 22174445, 19819937, 16895557)

Specifications

Accession Number P05113
Formulation 1 x PBS
Gene ID (Entrez) 3567
Molecular Weight (g/mol) 35-38 kDa
Quantity 1000 μg
Source HEK293
Storage Requirements Lyophilized product should be stored at -20°C to -80°C until expiry date and (at Room Temperature for 2 weeks.)
Endotoxin Concentration <0.1 EU/μg
Specific Reactivity Human
Recombinant Recombinant
Reconstitution Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile 1 xPBS containing 0.1% endotoxin-free recombinant human serum albumin (HSA).
Activity 0.2-0.9 ng/mL EC50
Form Lyophilized
Purity or Quality Grade >95%
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