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Proteintech HumanKine™ recombinant human IL-5 protein
HumanKine™ recombinant protein
Brand: Proteintech HZ-1324-10UG
Additional Details : Weight : 0.00010kg
Description
IL-5 is a 4-α-helix, pleiotropic cytokine that regulates the activities of B cells, eosinophils, and basophils. It is produced mostly by CD4+ T cells, eosinophils, and basophils, and signals through its specific receptor (IL-5R) on target cells to activate downstream JAK/STAT, Btk, and Ras/ERk pathways. Due to its pleiotropic effects, IL-5 plays a role in both innate and adaptive immune responses. It is a strong promoter of eosinophil differentiation, migration, maturation, and survival. Additionally, IL-5 is also capable of stimulating activated B cells to differentiate into antibody-secreting cells. Elevated IL-5 levels are strongly correlated with eosinophilia, which is a hallmark feature of allergy, asthma, and hypersensitivity (PMID: 21986312, 22174445, 19819937, 16895557)Specifications
| P05113 | |
| 3567 | |
| 10 μg | |
| Lyophilized product should be stored at -20°C to -80°C until expiry date and (at Room Temperature for 2 weeks.) | |
| Human | |
| Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile 1 xPBS containing 0.1% endotoxin-free recombinant human serum albumin (HSA). | |
| Lyophilized |
| 1 x PBS | |
| 35-38 kDa | |
| HEK293 | |
| <0.1 EU/μg | |
| Recombinant | |
| 0.2-0.9 ng/mL EC50 | |
| >95% |