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Gibco™ Human WISP-3 Recombinant Protein, PeproTech®

Product Code. 17880973
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Quantity:
100 μg
2 x 250 μg
20 μg
250 μg
4 x 250 μg
5 μg
Unit Size:
100µg
1mg
20µg
250µg
500µg
5µg
Pack of 2
Pack of 4
Product Code. Quantity unitSize
17880973 100 μg 100µg
17830123 4 x 250 μg 1mg
30089693 4 x 250 μg Pack of 4
17810313 20 μg 20µg
30089385 2 x 250 μg Pack of 2
17880293 250 μg 250µg
17871553 2 x 250 μg 500µg
17850803 5 μg 5µg
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Product Code. 17880973

Brand: Gibco™ 12020100UG

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Description

Recombinant Protein

120-20-1MG will be provided as 4 x 250 μg (120-20-250UG). 120-20-500UG will be provided as 2 x 250 μg (120-20-250UG). Recombinant Human WISP-3 is a 36.8 kDa protein containing 331 amino acid residues. It is composed of four distinct structural domains (modules): the IGF binding protein (IGFBP) domain, the von Willebrand Factor C (VWFC) domain, the thrombospondin type-1 repeat (TSP type-1) domain, and a C-terminal cysteine knot-like (CTCK) domain. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

WISP3 is a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. WISP3 is overexpressed in colon tumors. It may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Mutations of the WISP3 gene are associated with progressive pseudorheumatoid dysplasia, an autosomal recessive skeletal disorder, indicating that the gene is essential for normal postnatal skeletal growth and cartilage homeostasis.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number O95389
For Use With (Application) Functional Assay
Formulation protein with no preservative
Gene ID (Entrez) 8838
Molecular Weight (g/mol) 36.8 kDa
Name Human WISP-3
Quantity 100 μg
Source E. coli
Regulatory Status RUO
Endotoxin Concentration <1 EU/ μg
Gene Alias CCN family member 6; CCN6; Cellular communication network factor 6; ENSMUSG00000062074; Gm735; LIBC; PPAC; PPD; RGD1564120; UNQ462/PRO790/PRO956; Wisp3; WISP-3; WNT1 inducible signaling pathway protein 3; WNT1-inducible-signaling pathway protein 3
Common Name WISP3
Gene Symbol CCN6
Biological Activity The ED50 was determined by the dose-dependant proliferation of the MCF-7 cell line. The expected ED50 for this effect is 0.2-0.3 ug/ml
Conjugate Unconjugated
Recombinant Recombinant
Sequence TGPLDTTPEG RPGEVSDAPQ RKQFCHWPCK CPQQKPRCPP GVSLVRDGCG CCKICAKQPG EICNEADLCD PHKGLYCDYS VDRPRYETGV CAYLVAVGCE FNQVHYHNGQ VFQPNPLFSC LCVSGAIGCT PLFIPKLAGS HCSGAKGGKK SDQSNCSLEP LLQQLSTSYK TMPAYRNLPL IWKKKCLVQA TKWTPCSRTC GMGISNRVTN ENSNCEMRKE KRLCYIQPCD SNILKTIKIP KGKTCQPTFQ LSKAEKFVFS GCSSTQSYKP TFCGICLDKR CCIPNKSKMI TIQFDCPNEG SFKWKMLWIT SCVCQRNCRE PGDIFSELKI L
Content And Storage -20°C
Expression System E. coli
Form Lyophilized
Purity or Quality Grade ≥ 98% by SDS-PAGE gel and HPLC analyses.
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