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ACROBiosystems Human VSIG3 Protein, Fc Tag

Brand:  ACROBiosystems VS3-H5258-1mg

Additional Details : Weight : 0.00010kg

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Product Code. 16448149

  • 32169.11 NOK / 1mg
Estimated Shipment: 19-01-2023
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Description

Description

VSIG3, also known as IGSF11, BT-IgSF, and CLMP, is a homophilic adhesion molecule that preferentially expressed in the brain. The function of VSIG3 is to stimulate cell growth through homophilic interactions. In clinical, the VSIG3 has been reported to as a novel target for cancer immunotherapy of gastrointestinal and hepatocellular carcinomas. In addition, VSIG-3 is also a ligand of B7 family member VISTA/PD-1H and inhibits human T-cell functions through a novel VSIG-3/VISTA pathway. VSIG-3/VISTA co-inhibitory pathway may provide new strategies for the treatment of human cancers and autoimmune disorders.

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 49.7 kDa. The protein migrates as 60-65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Specifications

Specifications

NP_001015887.1
49.7 kDa
1 mg
Leu 23 - Gly 241
VSIG3,IgSF11,CXADRL1,Bt-IgSF,CT119
Unconjugated
Tris with Glycine, Arginine and NaCl, pH7.5
HEK293
Human
Powder
>95% as determined by SDS-PAGE
Human VSIG3, Fc Tag (VS3-H5258) is expressed from human 293 cells (HEK293). It contains AA Leu 23 - Gly 241 (Accession # Q5D x 21-1).
-20°C
VSIG3
Fc Tag
Less than 1.0 EU / µg by the LAL method.
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