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Gibco™ Human Sonic Hedgehog C25II Recombinant Protein, PeproTech®
E. coli Recombinant Protein
776.00 NOK - 27060.00 NOK
Specifications
Accession Number | Q15465 |
---|---|
For Use With (Application) | Functional Assay |
Formulation | protein with no preservative |
Gene ID (Entrez) | 6469 |
Molecular Weight (g/mol) | 20 |
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
---|---|---|---|---|---|---|---|---|---|
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
17801243
|
Gibco™
100-45-100UG |
100 μg |
5460.00 NOK
100µg |
In Stock Log in to see stock. |
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17890843
|
Gibco™
100-45-1MG |
2 x 500 μg |
27060.00 NOK
1mg |
Estimated Shipment: 24-05-2024 Log in to see stock. |
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17830853
|
Gibco™
100-45-250UG |
250 μg |
9470.00 NOK
250µg |
In Stock Log in to see stock. |
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17820363
|
Gibco™
100-45-25UG |
25 μg |
1888.00 NOK
25µg |
In Stock Log in to see stock. |
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17860093
|
Gibco™
100-45-500UG |
500 μg |
16270.00 NOK
500µg |
In Stock Log in to see stock. |
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17870843
|
Gibco™
100-45-5UG |
5 μg |
776.00 NOK
5µg |
Estimated Shipment: 24-05-2024 Log in to see stock. |
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Description
Sonic Hedgehog (SHH), which is expressed only during embryogenesis, is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the Sonic Hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved, the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE), a disorder in which the developing forebrain fails to correctly separate into right and left hemispheres. HPE is manifested by facial deformities. In addition, it is thought that mutations in this gene or in its signalling pathway may be responsible for VACTERL syndrome, which is characterized by vertebral defects, anal atresia, tracheoesophageal fistula with esophageal atresia, radial and renal dysplasia, cardiac anomalies, and limb abnormalities.Specifications
Q15465 | |
protein with no preservative | |
20 | |
E. coli | |
RUO | |
9530036O11Rik; Dsh; fc83d08; hedgehog; hemimelic extra toes; Hhg1; HHG-1; HLP3; HPE3; Hx; Hxl3; M100081; MCOPCB5; morphogen; shh; Shh N-terminal processed signaling domains; Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains; shh.L; shha; ShhN; ShhNC; ShhNp; short digits; SMMCI; sonic hedgehog; sonic hedgehog a; sonic hedgehog homolog; sonic hedgehog L homeolog; sonic hedgehog protein; Sonic hedgehog protein 19 kDa product; Sonic hedgehog protein A; Sonic hedgehog protein A N-product; Sonic hedgehog protein N-product; sonic hedgehog signaling molecule; sonic hedgehog signaling molecule a; sonic-you; syu; TPT; TPTPS; vhh1; vhh-1; wu:fc83d08; XELAEV_18030676mg; Xhh; xshh; X-SHH | |
Human | |
Recombinant | |
Lyophilized |
Functional Assay | |
6469 | |
Human Sonic Hedgehog C25II | |
-20°C | |
<1 EU/μg | |
Shh | |
Unconjugated | |
IVIGPGRGFG KRRHPKKLTP LAYKQFIPNV AEKTLGASGR YEGKISRNSE RFKELTPNYN PDIIFKDEEN TGADRLMTQR CKDKLNALAI SVMNQWPGVK LRVTEGWDED GHHSEESLHY EGRALDITTS DRDRSKYGML ARLAVEAGFD WVYYESKAHI HCSVKAENSV AAKSGG | |
≥ 98% by SDS-PAGE gel and HPLC analyses. |