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Invitrogen™ Human SIK2 Synthetic Peptide
Description
This peptide corresponds to 16 amino acids near the center of human SIK2. PEP-1254 can be used as a blocking peptide with polyclonal antibody PA5-34339.
SNF1LK2 (QIK) is a serine/threonine kinase and is a salt-inducible kinase that belongs to the AMP-activated protein kinase family. SNF1LK2 negatively regulates CRE-binding protein (CREB) activity by phosphorylating the CREB-specific coactivator transducer of regulated CREB activity (TORC). SIK2 is thought to be part of a signaling cascade that regulates the expression and activity of the insulin-induced genes PGC-1'alpha and UCP-1 in brown adipocytes, impairment of which has been implicated in obesity and insulin resistance in human and animal models. SIK2 has also been reported as a key regulator for neuronal survival after ischemia, suppressing CREB-mediated gene expression after oxygen-glucose deprivation.
Specifications
Specifications
| Gene ID (Entrez) | 23235 |
| Species | Human |
| Purification Method | purified |
| Accession Number | Q9H0K1 |
| Common Name | SIK2 |
| Concentration | 200 μg/mL |
| Content And Storage | -20°C |
| Description | Synthetic Peptide |
| Format | Liquid |
| Formulation | PBS with 0.1% BSA and 0.02% sodium azide; pH 7.2 |
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