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Invitrogen™ Human RIP1 Synthetic Peptide

Product Code. 15225529
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Quantity:
50 μg
Unit Size:
50µg
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15225529 50 μg 50µg
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Product Code. 15225529 Supplier Invitrogen™ Supplier No. PEP1599
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Estimated Shipment: 19-08-2026
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Description

Synthetic Peptide

This peptide corresponds to 14 amino acids near the carboxy terminus of human RIP1. PEP-1599 can be used as a blocking peptide with polyclonal antibody PA5-34556. For use as a blocking peptide in Western blot, incubate the peptide with equal volume of antibody for 30 min at 37°C.

Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necrosis-inducing complex.
TRUSTED_SUSTAINABILITY

Specifications

Gene ID (Entrez) 8737
Species Human
Purification Method purified
Accession Number Q13546
Common Name RIP1
Concentration 200 μg/mL
Content And Storage -20°C
Description Synthetic Peptide
Format Liquid
Formulation PBS with 0.1% BSA and 0.02% sodium azide; pH 7.2
For Use With (Application) Blocking Assay, Control
Gene Alias cell death protein RIP; D330015H01Rik; FLJ39204; OTTHUMP00000015955; receptor (TNFRSF)-interacting serine-threonine kinase 1; receptor interacting serine/threonine kinase 1; receptor-interacting protein 1; receptor-interacting protein kinase 1; receptor-interacting serine/threonine-protein kinase 1; Rinp; RIP; RIP1; RIP-1; RIP1 (CT); RIPK1; serine/threonine-protein kinase RIP
Gene Symbol RIPK1
Lyophilized No
Preservative Sodium azide
Product Type Peptide
Quantity 50 μg
Regulatory Status RUO
Storage Buffer PBS
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