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STEMCELL Technologies Human Recombinant IL-2 (CHO-expressed)

Product Code. 15881468
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15881468 10 μg 10µg
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Product Code. 15881468 Supplier STEMCELL Technologies Supplier No. 78036.1

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Description

Interleukin 2

  • Interleukin 2 (IL-2) is a monomeric cytokine that was originally identified as a T cell growth factor
  • It binds to heterotrimeric receptors consisting of CD25, CD122, and CD132
  • Upon binding, it activates JAK3-, STAT5-, and AKT-dependent signaling pathways, which results in cellular proliferation and survival (Ma et al.) The majority of IL-2 is secreted by activated CD4+ and CD8+ T cells, although B cells and dendritic cells were found to produce IL-2 in small amounts
  • IL-2 downregulates immune responses to prevent autoimmunity during thymic development, influences the development of CD4+CD25+ regulatory T cells, and affects development of follicular helper T cells
  • IL-2 also controls inflammation by inhibiting Th17 differentiation
  • Human Recombinant IL-2 has a serine substitute for cysteine at position 126

Specifications

Name Aldesleukin, Interleukin-2, T cell growth factor, TCGF
Quantity 10 μg
Cell Type Hematopoietic Stem and Progenitor Cells; NK Cells; T Cells; T Cells, CD4+; T Cells, CD8+
Purity or Quality Grade ≥95%
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