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Gibco™ Human OX40 Ligand (soluble) Recombinant Protein, PeproTech®

Product Code. 17852293
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17852293 100 μg 100µg
17862663 10 μg 10µg
17862193 1 mg 1mg
17852363 250 μg 250µg
17862493 2 μg 2µg
17872463 500 μg 500µg
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Product Code. 17852293 Supplier Gibco™ Supplier No. 31028100UG

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Description

Recombinant Protein

Recombinant OX40L is a glycosylated 133 amino acid protein corresponding to the extracellular TNF homologous domain of the full length transmembrane protein. It migrates with an apparent molecular mass of 15.5-25.0 kDa on SDS-PAGE. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

The tumor necrosis factor superfamily member TNFSF4 is a type II membrane bound, non-covalently linked homotrimeric protein. It is expressed on antigen presenting cells, such as dendritic cells and activated B-cells, and also on other cells such as vascular endothelial cells, mast cells, and natural killer cells. TNFSF4 signals specifically through the TNFRSF4 receptor, is expressed predominantly on CD4+T cells but also on certain activated CD8+T cells. TNFRSF4/TNFSF4 functions as a costimulatory signal, which is required for a productive interaction between antigen presenting cells and their target T-cells. It enhances cell proliferation and survival, and increases expression of RANTES, IL-2, IL-3, and IFNgamma. TNFRSF4/TNFSF4 signaling plays an important role in immunotolerance.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number P23510
For Use With (Application) Control, ELISA Standard, Binding Assay, Bioactivity
Formulation Protein with no preservative
Gene ID (Entrez) 7292
Molecular Weight (g/mol) 15.4 kDa
Name Human OX40 Ligand (soluble)
Purification Method Purified
Quantity 100 μg
Source Insect cells
Storage Requirements -20°C
Regulatory Status RUO
Endotoxin Concentration <1 EU/μg
Gene Alias Ath1; Ath-1; atherosclerosis 1; CD134 ligand; CD134L; CD252; glycoprotein Gp34; GP34; OX40 antigen ligand; OX40 ligand; OX40L; OX-40L; OX4OL; TAX transcriptionally-activated glycoprotein 1; tax-transcriptionally activated glycoprotein 1 (34kD); tax-transcriptionally activated glycoprotein 1 ligand; TNFSF4; TNLG2B; tumor necrosis factor (ligand) superfamily member 4; tumor necrosis factor (ligand) superfamily, member 4; tumor necrosis factor ligand 2B; tumor necrosis factor ligand superfamily member 4; tumor necrosis factor superfamily member 4; TXGP1; Txgp1l
Common Name OX40L (CD252)
Gene Symbol Tnfsf4
Biological Activity Determined by its ability to bind hOX40 in a functional ELISA.
Product Type Protein
Conjugate Unconjugated
Recombinant Recombinant
Sequence QVSHRYPRIQ SIKVQFTEYK KEKGFILTSQ KEDEIMKVQN NSVIINCDGF YLISLKGYFS QEVNISLHYQ KDEEPLFQLK KVRSVNSLMV ASLTYKDKVY LNVTTDNTSL DDFHVNGGEL ILIHQNPGEF CVL
Content And Storage -20°C
Activity Determined by its ability to bind hOX40 in a functional ELISA.
Expression System Insect cells
Form Lyophilized
Purity or Quality Grade ≥ 97% by SDS-PAGE gel and HPLC analyses.
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