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Invitrogen™ Human Osteopontin Synthetic Peptide
Description
This peptide corresponds to 18 amino acids near the amino terminus of SPP1. PEP-1622 can be used as a blocking peptide with polyclonal antibody PA5-34579. For use as a blocking peptide in Western blot, incubate the peptide with equal volume of antibody for 30 min at 37°C.
Osteopontin is an arginine-glycine-aspartic acid (RGD)-containing glycoprotein that interacts with integrins and CD44 as major receptors. It is a multifunctional protein involved in bone mineralization, cell adhesion, cell migration, chronic inflammatory disease and transformation. Proteolytic cleavage by thrombin and matrix metalloproteinases close to the integrin-binding Arg-Gly-Asp sequence modulates the function of OPN and its integrin binding properties. Thrombin-cleaved fragments of Osteopontin are overexpressed in malignant glial tumors and provide a molecular niche with survival advantage and provide a novel substrate for plasmin and cathepsin D.
Specifications
Specifications
| Gene ID (Entrez) | 6696 |
| Species | Human |
| Purification Method | purified |
| Accession Number | P10451 |
| Common Name | Osteopontin |
| Concentration | 200 μg/mL |
| Content And Storage | -20°C |
| Description | Synthetic Peptide |
| Format | Liquid |
| Formulation | PBS with 0.1% BSA and 0.02% sodium azide; pH 7.2 |
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Product Title
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