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Gibco™ Human Oncostatin M (227 aa) Recombinant Protein, PeproTech®

Product Code. 17881603
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Product Code. Quantity unitSize
17881603 100 μg 100µg
17891003 10 μg 10µg
17820243 1 mg 1mg
17871203 250 μg 250µg
17800633 2 μg 2µg
17861713 500 μg 500µg
17831603 50 μg 50µg
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Product Code. 17881603

Brand: Gibco™ 30010100UG

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Description

Recombinant Protein

Recombinant Human Oncostatin M is a 25.7 kDa protein, containing 227 amino acid residues (full length precursor). This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Oncostatin M (OSM) is a growth and differentiation factor that participates in the regulation of neurogenesis, osteogenesis and hematopoiesis. Produced by activated T cells, monocytes and Kaposi's sarcoma cells, OSM can exert both stimulatory and inhibitory effects on cell proliferation. It stimulates the proliferation of fibroblasts, smooth muscle cells and Kaposi's sarcoma cells, but inhibits the growth of some normal and tumor cell lines. It also promotes cytokine release (e.g. IL-6, GM-CSF and G-CSF) from endothelial cells, and enhances the expression of low-density lipoprotein receptors in hepatoma cells. OSM shares several structural and functional characteristics with LIF, IL-6, and CNTF.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number P13725
For Use With (Application) ELISA, Functional Assay, Western Blot
Formulation protein with no preservative
Gene ID (Entrez) 5008
Molecular Weight (g/mol) 25.7 kDa
Name Human Oncostatin M (227 aa)
Quantity 100 μg
Source E. coli
Regulatory Status RUO
Endotoxin Concentration <1 EU/ μg
Gene Alias MGC20461; OncoM; oncostatin M; oncostatin-M; OSM
Common Name Oncostatin M
Gene Symbol OSM
Biological Activity The ED50 as determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is ≤ 2 ng/ml, corresponding to a specific activity of ≥ 5 x 10^5 units/mg
Conjugate Unconjugated
Recombinant Recombinant
Sequence AAIGSCSKEY RVLLGQLQKQ TDLMQDTSRL LDPYIRIQGL DVPKLREHCR ERPGAFPSEE TLRGLGRRGF LQTLNATLGC VLHRLADLEQ RLPKAQDLER SGLNIEDLEK LQMARPNILG LRNNIYCMAQ LLDNSDTAEP TKAGRGASQP PTPTPASDAF QRKLEGCRFL HGYHRFMHSV GRVFSKWGES PNRSRRHSPH QALRKGVRRT RPSRKGKRLM TRGQLPR
Content And Storage -20°C
Expression System E. coli
Form Lyophilized
Purity or Quality Grade ≥ 98% by SDS-PAGE gel and HPLC analyses.
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