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ACROBiosystems Human NOTCH1 Protein, Fc Tag
MALS verified
Brand: ACROBiosystems NO1-H5255-100ug
Additional Details : Weight : 0.00010kg
Description
NOTCH1 Interacts with DNER, DTX1, DTX2 and RBPJ/RBPSUH. Also interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH1. The NOTCH1 intracellular domain interacts with SNW1; the interaction involves multimerized NOTCH1 NICD and is implicated in a formation of an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ. The activated membrane-bound form interacts with AAK1 which promotes NOTCH1 stabilization. Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia.
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 80.0 kDa. The protein migrates as 90-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.Specifications
| NP_060087.3 | |
| 100 µg | |
| Ala 19 - Gln 526 | |
| NOTCH1,Notch 1,hN1,TAN1 | |
| Unconjugated | |
| Fc Tag | |
| Less than 1.0 EU / µg by the LAL method. | |
| Powder | |
| >95% as determined by SDS-PAGE |
| 80.0 kDa | |
| Human NOTCH1, Fc Tag (NO1-H5255) is expressed from human 293 cells (HEK293). It contains AA Ala 19 - Gln 526 (Accession # P46531-1). | |
| -20°C | |
| NOTCH1 | |
| Human | |
| PBS, pH7.4 | |
| HEK293 | |
| Other Recombinant Proteins |