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Gibco™ Human LIGHT Recombinant Protein, PeproTech®

Product Code. 17882233
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Quantity:
15 μg
17 x 15 μg
3 μg
34 x 15 μg
67 x 15 μg
7 x 15 μg
Unit Size:
100µg
15µg
1mg
250µg
3µg
500µg
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Product Code. 17882233

Brand: Gibco™ 31009B15UG

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This item is not returnable. View return policy

Description

Recombinant Protein

310-09B-100UG will be provided as 15 μg (310-09B-15UG) vials. 310-09B-1MG will be provided as 15 μg (310-09B-15UG) vials. 310-09B-250UG will be provided as 15 μg (310-09B-15UG) vials. 310-09B-500UG will be provided as 15 μg (310-09B-15UG) vials. Recombinant Human LIGHT has a calculated mass of 19.3 kDa, containing 177 amino acid residues. Due to glycosylation, LIGHT migrates between 20.0-22.5 kDa by SDS-PAGE under non-reducing conditions. *Human LIGHT(Catalog Number 310-09B) has replaced Human LIGHT(Catalog Number 310-09) This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF (tumor necrosis factor) and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 (tumor necrosis factor receptor 1) and Fas. Cell death signals are transduced by death domain (DD)-containing adapter molecules and members of the ICE (interleukin-1-beta converting enzyme)/CED-3 (C. elegans death receptor-3) protease family. A novel DD-containing molecule was recently cloned from mouse, human and monkey and designated Daxx (death associated protein 6). Daxx binds specifically to the Fas death domain and enhances Fas induced apoptosis and activates the Jun N-terminal kinase (JNK) pathway. Daxx is widely expressed in fetal and adult human and mouse tissues indicating its important function in Fas signaling pathways.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number O43557
For Use With (Application) Control, Western Blot Control, Bioactivity
Formulation Protein with no preservative
Gene ID (Entrez) 8740
Molecular Weight (g/mol) 19.3 kDa
Name Human LIGHT
Purification Method Purified
Quantity 15 μg
Source Insect cells
Storage Requirements -20°C
Regulatory Status RUO
Endotoxin Concentration <1 EU/μg
Gene Alias CD258; Herpes virus entry mediator ligand; herpesvirus entry mediator ligand; HVEML; HVEM-L; Light; LTg; Ly113; sCD258; sLIGHT; soluble CD258; soluble LIGHT; Tnfsf14; TR2; tumor necrosis factor (ligand) superfamily, member 14; tumor necrosis factor ligand 1D; tumor necrosis factor ligand superfamily member 14; Tumor necrosis factor ligand superfamily member 14, membrane form; Tumor necrosis factor ligand superfamily member 14, soluble form; tumor necrosis factor superfamily member 14; UNQ391/PRO726
Common Name LIGHT
Gene Symbol TNFSF14
Biological Activity Determined by its ability to induce IL-8 secretion in human BEAS-2 B cells.
Product Type Protein
Conjugate Unconjugated
Recombinant Recombinant
Sequence RLGEMVTRLP DGPAGSWEQL IQERRSHEVN PAAHLTGANS SLTGSGGPLL WETQLGLAFL RGLSYHDGAL VVTKAGYYYI YSKVQLGGVG CPLGLASTIT HGLYKRTPRY PEELELLVSQ QSPCGRATSS SRVWWDSSFL GGVVHLEAGE KVVVRVLDER LVRLRDGTRS YFGAFMV
Content And Storage -20°C
Activity Determined by its ability to induce IL-8 secretion in human BEAS-2B cells.
Expression System Insect cells
Form Lyophilized
Purity or Quality Grade ≥ 95% by SDS-PAGE gel and HPLC analyses.
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