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Invitrogen™ Human IL-31, AOF Recombinant Protein
Description
Interleukin-31 (IL-31) is a recently discovered T-cell cytokine closely related to IL-6 type cytokines and is preferentially produced by T helper type 2 cells. IL-31 activity is mediated through the ligand-induced oligomerization of a dimeric receptor complex containing IL-31 receptor A and oncostatin M receptor. In response to IL-31 binding, these proteins activate the JAK/STAT and the AKT signaling pathways. RNA levels of IL-31 receptor A and oncostatin M receptor are induced in activated monocytes but are expressed constitutively in epithelial cells. IL-31, when overexpressed in transgenic mice, results in the development of pruritis, alopecia, and skin lesions and in humans may result in atopic dermatitis, suggesting that IL-31 may represent a novel target for antipruritic drug development.
- Purity: >95% by SDS-Page
- Endotoxin Concentration: AX41 ≤EUs/μg
- Protein Length: 141 aa.
- Biological Activity: <25 ng/mL
- Molecular Weight: 15.8 kDa
- Animal Origin Free: Yes
Specifications
Specifications
| Accession Number | Q6EBC2 |
| For Use With (Application) | Control, ELISA, Functional Assay, Western Blot |
| Formulation | 20 mM sodium phosphate with 50 mM NaCl and no preservative |
| Gene ID (Entrez) | 386653 |
| Molecular Weight (g/mol) | 15.8 kDa |
| Name | Human IL-31, AOF |
| Quantity | 25 μg |
| Source | E. coli |
| Storage Requirements | -20°C |
| Regulatory Status | RUO |
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Product Title
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