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Invitrogen™ Human ICAM-1 (CD54) Recombinant Protein

Product Code. 11598961
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Quantity:
1 mg
Unit Size:
1mg
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Product Code. 11598961

Brand: Invitrogen™ RP75643

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This item is not returnable. View return policy

Description

Recombinant Protein

This product contains purified recombinant human ICAM-1 protein with an N-terminal hexahistidine tag. This product may be used as a positive control in many immunological assays.

ICAM-1 (CD54) is an 85-110 kDa single-chain type 1 integral membrane glycoprotein with an extracellular domain of five immunoglobulin superfamily repeats, a transmembrane region and a cytoplasmic domain. ICAM-1 has 7 potential N-linked glycosylation sites and shares considerable amino acid sequence homology with ICAM-3 (CD50) and ICAM-2 (CD102). ICAM-1 binds to integrins of type CD11a/CD18 (leukocyte adhesion molecule, LFA-1), or CD11b/CD18 (Mac-1) and is exploited by Rhinovirus as a receptor. ICAM-1 is expressed by activated endothelial cells and detected on epithelial cells, fibroblasts, chondrocytes, B lymphocytes, T lymphocytes (low), monocytes, macrophages, dendritic cells and neutrophils, with lower levels that increase upon inflammation. ICAM-1 is also detected in some carcinoma and melanoma cells. Soluble ICAM-1 is detectable in the plasma and is elevated in patients with various inflammatory syndromes.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number P05362
Concentration 1 mg/mL
For Use With (Application) Control, Western Blot
Formulation 0.02 M tris HCl with 50% glycerol and no preservative; pH 8
Gene ID (Entrez) 3383
Name Human ICAM-1 (CD54)
Quantity 1 mg
Source E. coli
Immunogen N/A
Regulatory Status RUO
Gene Alias BB2; CD54; cell surface glycoprotein P3.58; Human rhinovirus receptor; ICAM; Icam1; ICAM-1; ICAM-1; CD54 homolog; Intercellular adhesion molecule 1; intercellular adhesion molecule 1 (CD54), human rhinovirus receptor; intercellular adhesion molecule-1; intercellular adhesion molecule-1 precursor; Ly 47; Ly-47; major group rhinovirus receptor; MALA2; MALA-2; MyD10; P3.58; sCD54; soluble CD54; Surface antigen of activated B cells
Common Name ICAM-1 (CD54)
Gene Symbol ICAM1
Conjugate Unconjugated
Species E. coli
Recombinant Recombinant
Protein Tag His-tag
Sequence Amino acids Gln28- Val482 containing an N-terminal His-tag
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Expression System E. coli
Form Liquid
Protein Subtype Recombinant
Purity or Quality Grade >95%, by SDS-PAGE under reducing conditions
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