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Gibco™ Human Growth Hormone Recombinant Protein, PeproTech®

Product Code. 17871333
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Product Code. Quantity unitSize
17871333 100 μg 100µg
17851633 10 μg 10µg
17841033 1 mg 1mg
17801233 250 μg 250µg
17879992 500 μg 500µg
17840093 50 μg 50µg
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Product Code. 17871333 Supplier Gibco™ Supplier No. 10040100UG

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Description

Recombinant Protein

Recombinant Human Growth Hormone is a 22.3 kDa, single, non-glycosylated polypeptide chain containing 192 amino acid residues. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Human growth hormone (hGH) is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The GH1 gene, along with 4 additional related genes, is located at the growth hormone locus on chromosome 17. The five genes share a remarkably high degree of sequence identity. Alternative splicing results in 5 isoforms ranging from approximately 19 kDa to 24 kDa. HGH is produced by the somatotroph cells in the pituitary. It acts through binding to membrane receptors that belong to the cytokine receptor subfamily. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues. Mutations or deletions in the gene lead to growth hormone deficiency and short stature.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number P01241
For Use With (Application) Functional Assay
Formulation protein with no preservative
Gene ID (Entrez) 2688
Molecular Weight (g/mol) 22.3 kDa
Name Human Growth Hormone
Quantity 100 μg
Source E. coli
Regulatory Status RUO
Endotoxin Concentration <1 EU/ μg
Gene Alias dog growth hormone; GH; Gh1; GHB1; GHB5; GHN; GH-N; Growth hormone; growth hormone 1; growth hormone 12; growth hormone B1; growth hormone B5; growth hormone precursor; HGH; hGH-N; IGHD1B; pituitary growth hormone; RNGHGP; Somatotropin
Common Name Growth Hormone
Gene Symbol Gh1
Biological Activity Determined by its ability to stimulate the proliferation of rat Nb2-11 cells. The expected ED50 is = 0.05 ng/ml, corresponding to a specific activity of = 2 x 10^7 units/mg
Conjugate Unconjugated
Recombinant Recombinant
Sequence MFPTIPLSRL FDNAMLRAHR LHQLAFDTYQ EFEEAYIPKE QKYSFLQNPQ TSLCFSESIP TPSNREETQQ KSNLELLRIS LLLIQSWLEP VQFLRSVFAN SLVYGASDSN VYDLLKDLEE GIQTLMGRLE DGSPRTGQIF KQTYSKFDTN SHNDDALLKN YGLLYCFRKD MDKVETFLRI VQCRSVEGSC GF
Content And Storage -20°C
Expression System E. coli
Form Lyophilized
Purity or Quality Grade ≥ 98% by SDS-PAGE gel and HPLC analyses.
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