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Invitrogen™ Human DLL4 Fc Chimera, Recombinant Protein
HEK293 cells Recombinant Protein
Brand: Invitrogen™ A42511
Additional Details : Weight : 0.01810kg
Description
Delta-like ligand 4 (DLL4), also know as Delta-4, is a homologue of the Drosophila delta protein, and functions as a transmembrane bound ligand to the notch receptor Notch1. DLL4 is expressed in the vasculature and plays a critical role in vascular development. It is induced by vascular endothelial growth factor (VEGF), as a negative feedback regulator to regulate angiogenic sprouting and promote the formulation of a differentiated vascular network. DLL4 has been found to be strongly expressed in tumor vessels of clear-cell renal tumors and bladder cancer, and inhibition of DLL4 results in increased vascular proliferation but defective maturation. This in turn leads to a decrease in tumor growth, with no apparent toxicity.Specifications
| Q9NR61 | |
| protein with 0.02% Tween 80, 140 mM NaCl, 2.7 mM KCl, 5% mannitol, 5% trehalose and no preservative | |
| Human DLL4 Fc Chimera | |
| HEK293 cells | |
| RUO | |
| AOS6; delta 4; delta ligand 4; delta like canonical Notch ligand 4; Delta4; delta-like 4 (Drosophila); delta-like 4 homolog; delta-like 4 protein; delta-like protein 4; DLL4; Drosophila Delta homolog 4; hdelta2; MGC126344; notch ligand delta-2; notch ligand DLL4; UNQ1895/PRO4341 | |
| Human | |
| Recombinant | |
| ≥ 90% |
| Control, ELISA, Functional Assay, Immunohistochemistry, Western Blot | |
| 54567 | |
| 5 x 50 μg | |
| -20°C | |
| <1 EU/μg | |
| Dll4 | |
| Unconjugated | |
| Lyophilized |